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Osteoporotic fracture

MedGen UID:
101059
•Concept ID:
C0521170
•
Disease or Syndrome
Synonyms: Fracture, Osteoporotic; Fractures, Osteoporotic; Osteoporotic Fracture; Osteoporotic Fractures
SNOMED CT: Osteoporotic fracture (443165006); Osteoporotic fracture of bone (443165006); Osteoporotic fracture (46675001)

Definition

A pathologic bone fracture due to osteoporosis. It is generally caused by a fall from a standing height or lower and usually involves the spine, hip, or wrist. [from NCI]

Professional guidelines

PubMed

Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Guideline Update.
Shoback D, Rosen CJ, Black DM, Cheung AM, Murad MH, Eastell R
J Clin Endocrinol Metab 2020 Mar 1;105(3) doi: 10.1210/clinem/dgaa048. PMID: 32068863
Exercise and Sports Science Australia (ESSA) position statement on exercise prescription for the prevention and management of osteoporosis.
Beck BR, Daly RM, Singh MA, Taaffe DR
J Sci Med Sport 2017 May;20(5):438-445. Epub 2016 Oct 31 doi: 10.1016/j.jsams.2016.10.001. PMID: 27840033
Osteoporosis in elderly: prevention and treatment.
Srivastava M, Deal C
Clin Geriatr Med 2002 Aug;18(3):529-55. doi: 10.1016/s0749-0690(02)00022-8. PMID: 12424871

Recent clinical studies

Etiology

Predictors of osteoporotic fracture in postmenopausal women: a meta-analysis.
Long G, Liu C, Liang T, Zhang Z, Qin Z, Zhan X
J Orthop Surg Res 2023 Aug 5;18(1):574. doi: 10.1186/s13018-023-04051-6. PMID: 37543616Free PMC Article
Proton Pump Inhibitors and Bone Health: An Update Narrative Review.
Lespessailles E, Toumi H
Int J Mol Sci 2022 Sep 14;23(18) doi: 10.3390/ijms231810733. PMID: 36142643Free PMC Article
Treatment of osteoporotic vertebral fractures.
Prost S, Pesenti S, Fuentes S, Tropiano P, Blondel B
Orthop Traumatol Surg Res 2021 Feb;107(1S):102779. Epub 2020 Dec 13 doi: 10.1016/j.otsr.2020.102779. PMID: 33321233
A systematic review of hip fracture incidence and probability of fracture worldwide.
Kanis JA, Odén A, McCloskey EV, Johansson H, Wahl DA, Cooper C; IOF Working Group on Epidemiology and Quality of Life
Osteoporos Int 2012 Sep;23(9):2239-56. Epub 2012 Mar 15 doi: 10.1007/s00198-012-1964-3. PMID: 22419370Free PMC Article
Epidemiology, etiology, and diagnosis of osteoporosis.
Lane NE
Am J Obstet Gynecol 2006 Feb;194(2 Suppl):S3-11. doi: 10.1016/j.ajog.2005.08.047. PMID: 16448873

Diagnosis

Treatment of osteoporotic vertebral fractures.
Prost S, Pesenti S, Fuentes S, Tropiano P, Blondel B
Orthop Traumatol Surg Res 2021 Feb;107(1S):102779. Epub 2020 Dec 13 doi: 10.1016/j.otsr.2020.102779. PMID: 33321233
A road map for understanding molecular and genetic determinants of osteoporosis.
Yang TL, Shen H, Liu A, Dong SS, Zhang L, Deng FY, Zhao Q, Deng HW
Nat Rev Endocrinol 2020 Feb;16(2):91-103. Epub 2019 Dec 2 doi: 10.1038/s41574-019-0282-7. PMID: 31792439Free PMC Article
Prevention and rehabilitation of osteoporosis.
Kerschan-Schindl K
Wien Med Wochenschr 2016 Feb;166(1-2):22-7. Epub 2016 Jan 14 doi: 10.1007/s10354-015-0417-y. PMID: 26769298
Epidemiology, etiology, and diagnosis of osteoporosis.
Lane NE
Am J Obstet Gynecol 2006 Feb;194(2 Suppl):S3-11. doi: 10.1016/j.ajog.2005.08.047. PMID: 16448873
Osteoporosis in elderly: prevention and treatment.
Srivastava M, Deal C
Clin Geriatr Med 2002 Aug;18(3):529-55. doi: 10.1016/s0749-0690(02)00022-8. PMID: 12424871

Therapy

Proton Pump Inhibitors and Bone Health: An Update Narrative Review.
Lespessailles E, Toumi H
Int J Mol Sci 2022 Sep 14;23(18) doi: 10.3390/ijms231810733. PMID: 36142643Free PMC Article
Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Guideline Update.
Shoback D, Rosen CJ, Black DM, Cheung AM, Murad MH, Eastell R
J Clin Endocrinol Metab 2020 Mar 1;105(3) doi: 10.1210/clinem/dgaa048. PMID: 32068863
Comparison of Denosumab and Bisphosphonates in Patients With Osteoporosis: A Meta-Analysis of Randomized Controlled Trials.
Lyu H, Jundi B, Xu C, Tedeschi SK, Yoshida K, Zhao S, Nigwekar SU, Leder BZ, Solomon DH
J Clin Endocrinol Metab 2019 May 1;104(5):1753-1765. doi: 10.1210/jc.2018-02236. PMID: 30535289Free PMC Article
Exercise and Sports Science Australia (ESSA) position statement on exercise prescription for the prevention and management of osteoporosis.
Beck BR, Daly RM, Singh MA, Taaffe DR
J Sci Med Sport 2017 May;20(5):438-445. Epub 2016 Oct 31 doi: 10.1016/j.jsams.2016.10.001. PMID: 27840033
Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial.
Miller PD, Hattersley G, Riis BJ, Williams GC, Lau E, Russo LA, Alexandersen P, Zerbini CA, Hu MY, Harris AG, Fitzpatrick LA, Cosman F, Christiansen C; ACTIVE Study Investigators
JAMA 2016 Aug 16;316(7):722-33. doi: 10.1001/jama.2016.11136. PMID: 27533157

Prognosis

Update on trabecular bone score.
Palomo T, Muszkat P, Weiler FG, Dreyer P, Brandão CMA, Silva BC
Arch Endocrinol Metab 2022 Nov 11;66(5):694-706. doi: 10.20945/2359-3997000000559. PMID: 36382759Free PMC Article
Epidemiology of distal radius fractures and factors predicting risk and prognosis.
MacIntyre NJ, Dewan N
J Hand Ther 2016 Apr-Jun;29(2):136-45. doi: 10.1016/j.jht.2016.03.003. PMID: 27264899
Osteoporosis.
Nanes MS, Kallen CB
Semin Nucl Med 2014;44(6):439-50. doi: 10.1053/j.semnuclmed.2014.06.006. PMID: 25362234
A systematic review of hip fracture incidence and probability of fracture worldwide.
Kanis JA, Odén A, McCloskey EV, Johansson H, Wahl DA, Cooper C; IOF Working Group on Epidemiology and Quality of Life
Osteoporos Int 2012 Sep;23(9):2239-56. Epub 2012 Mar 15 doi: 10.1007/s00198-012-1964-3. PMID: 22419370Free PMC Article
An estimate of the worldwide prevalence and disability associated with osteoporotic fractures.
Johnell O, Kanis JA
Osteoporos Int 2006 Dec;17(12):1726-33. Epub 2006 Sep 16 doi: 10.1007/s00198-006-0172-4. PMID: 16983459

Clinical prediction guides

Predictors of osteoporotic fracture in postmenopausal women: a meta-analysis.
Long G, Liu C, Liang T, Zhang Z, Qin Z, Zhan X
J Orthop Surg Res 2023 Aug 5;18(1):574. doi: 10.1186/s13018-023-04051-6. PMID: 37543616Free PMC Article
Update on trabecular bone score.
Palomo T, Muszkat P, Weiler FG, Dreyer P, Brandão CMA, Silva BC
Arch Endocrinol Metab 2022 Nov 11;66(5):694-706. doi: 10.20945/2359-3997000000559. PMID: 36382759Free PMC Article
Fracture prediction tools in diabetes.
Agarwal A, Leslie WD
Curr Opin Endocrinol Diabetes Obes 2022 Aug 1;29(4):326-332. Epub 2022 Jun 24 doi: 10.1097/MED.0000000000000734. PMID: 35749735
Determinants of imminent fracture risk in postmenopausal women with osteoporosis.
Barron RL, Oster G, Grauer A, Crittenden DB, Weycker D
Osteoporos Int 2020 Nov;31(11):2103-2111. Epub 2020 Jul 1 doi: 10.1007/s00198-020-05294-3. PMID: 32613410Free PMC Article
Epidemiology of distal radius fractures and factors predicting risk and prognosis.
MacIntyre NJ, Dewan N
J Hand Ther 2016 Apr-Jun;29(2):136-45. doi: 10.1016/j.jht.2016.03.003. PMID: 27264899

Recent systematic reviews

Predictors of osteoporotic fracture in postmenopausal women: a meta-analysis.
Long G, Liu C, Liang T, Zhang Z, Qin Z, Zhan X
J Orthop Surg Res 2023 Aug 5;18(1):574. doi: 10.1186/s13018-023-04051-6. PMID: 37543616Free PMC Article
Update on the clinical use of trabecular bone score (TBS) in the management of osteoporosis: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), and the International Osteoporosis Foundation (IOF) under the auspices of WHO Collaborating Center for Epidemiology of Musculoskeletal Health and Aging.
Shevroja E, Reginster JY, Lamy O, Al-Daghri N, Chandran M, Demoux-Baiada AL, Kohlmeier L, Lecart MP, Messina D, Camargos BM, Payer J, Tuzun S, Veronese N, Cooper C, McCloskey EV, Harvey NC
Osteoporos Int 2023 Sep;34(9):1501-1529. Epub 2023 Jul 1 doi: 10.1007/s00198-023-06817-4. PMID: 37393412Free PMC Article
Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan.
Vandenput L, Johansson H, McCloskey EV, Liu E, Åkesson KE, Anderson FA, Azagra R, Bager CL, Beaudart C, Bischoff-Ferrari HA, Biver E, Bruyère O, Cauley JA, Center JR, Chapurlat R, Christiansen C, Cooper C, Crandall CJ, Cummings SR, da Silva JAP, Dawson-Hughes B, Diez-Perez A, Dufour AB, Eisman JA, Elders PJM, Ferrari S, Fujita Y, Fujiwara S, Glüer CC, Goldshtein I, Goltzman D, Gudnason V, Hall J, Hans D, Hoff M, Hollick RJ, Huisman M, Iki M, Ish-Shalom S, Jones G, Karlsson MK, Khosla S, Kiel DP, Koh WP, Koromani F, Kotowicz MA, Kröger H, Kwok T, Lamy O, Langhammer A, Larijani B, Lippuner K, Mellström D, Merlijn T, Nordström A, Nordström P, O'Neill TW, Obermayer-Pietsch B, Ohlsson C, Orwoll ES, Pasco JA, Rivadeneira F, Schei B, Schott AM, Shiroma EJ, Siggeirsdottir K, Simonsick EM, Sornay-Rendu E, Sund R, Swart KMA, Szulc P, Tamaki J, Torgerson DJ, van Schoor NM, van Staa TP, Vila J, Wareham NJ, Wright NC, Yoshimura N, Zillikens MC, Zwart M, Harvey NC, Lorentzon M, Leslie WD, Kanis JA
Osteoporos Int 2022 Oct;33(10):2103-2136. Epub 2022 May 31 doi: 10.1007/s00198-022-06435-6. PMID: 35639106
Nutritional Support and Physical Modalities for People with Osteoporosis: Current Opinion.
Chen LR, Hou PH, Chen KH
Nutrients 2019 Nov 20;11(12) doi: 10.3390/nu11122848. PMID: 31757101Free PMC Article
A systematic review of hip fracture incidence and probability of fracture worldwide.
Kanis JA, Odén A, McCloskey EV, Johansson H, Wahl DA, Cooper C; IOF Working Group on Epidemiology and Quality of Life
Osteoporos Int 2012 Sep;23(9):2239-56. Epub 2012 Mar 15 doi: 10.1007/s00198-012-1964-3. PMID: 22419370Free PMC Article

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